Ipratropium 500mcg + Levosalbutamol 1.25mg Respules – IPRALITE DUO by Sarian Healthcare

Ipratropium 500mcg & Levosalbutamol 1.25mg | IPRALITE DUO RESPULES

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Respule formulation containing ipratropium 500mcg and levosalbutamol 1.25mg.

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Product Specifications

Composition: Each 2 ml Respule contains: Ipratropium 500mcg + Levosalbutamol 1.25 mg
Dosage Form: Drops
Therapeutic Categories: Anti-Asthmetics / Nurolytics / Expectorants
SKU: IPRALITE DUO RESPULES Category: Tags: , , , , Brand:

Description

IPRALITE DUO RESPULES contains Ipratropium 500mcg + Levosalbutamol 1.25mg, a combination of two short-acting bronchodilators used to help relieve bronchospasm and improve airflow in appropriate obstructive airway conditions.

Ipratropium is a short-acting muscarinic antagonist (SAMA) and anticholinergic bronchodilator, while Levosalbutamol (Levalbuterol) is a selective short-acting beta-2 adrenergic receptor agonist (SABA). Together, these ingredients provide complementary bronchodilator activity through different receptor pathways.

Each 2mL respule of IPRALITE DUO RESPULES contains Ipratropium 500mcg + Levosalbutamol 1.25mg and is supplied in an 8×5×2.5mL pack. The formulation is intended for administration through a suitable nebulization system as directed by a healthcare professional.

Ipratropium helps reduce cholinergic-mediated bronchoconstriction by blocking muscarinic receptors in the airways. Levosalbutamol stimulates beta-2 receptors in bronchial smooth muscle, promoting relaxation and airway widening.

The Ipratropium 500mcg + Levosalbutamol 1.25mg uses depend on the patient’s respiratory condition and clinical assessment. The combination may be used for symptomatic relief of airflow limitation associated with conditions such as chronic obstructive pulmonary disease (COPD) and other bronchospastic airway conditions where combination bronchodilation is prescribed.

It should not be assumed to be appropriate for every respiratory symptom. Persistent, severe, or worsening breathing difficulty requires appropriate medical assessment.

For healthcare professionals, pharmacists, distributors, stockists, and procurement teams searching for Ipratropium 500mcg + Levosalbutamol 1.25mg respules, Ipratropium + Levosalbutamol nebulizer solution, or related pharmaceutical sourcing requirements, IPRALITE DUO RESPULES is a Sarian Healthcare pharmaceutical product supplied for professional healthcare and B2B pharmaceutical channels.

IPRALITE DUO RESPULES Composition

Each 2mL respule contains:

  • Ipratropium – 500mcg
  • Levosalbutamol – 1.25mg

Dosage Form: Respule / Nebulizer Solution
Pack Size: 8×5×2.5mL
Manufacturer: Sarian Healthcare

What Is Ipratropium 500mcg + Levosalbutamol 1.25mg Used For?

Ipratropium 500mcg + Levosalbutamol 1.25mg is a combination bronchodilator used to help relieve bronchospasm and improve airflow when both anticholinergic and beta-2 agonist bronchodilation are clinically appropriate.

The combination may be used in selected obstructive airway conditions, including COPD and other bronchospastic respiratory conditions, according to the treating physician’s assessment.

Ipratropium helps reduce cholinergic-mediated airway constriction, while Levosalbutamol relaxes bronchial smooth muscle through beta-2 receptor stimulation.

The appropriate indication, dosage, frequency, and duration of treatment should be determined by a qualified healthcare professional.

Key Ingredients and Their Functions

1. Ipratropium – 500mcg

Active Ingredient: Ipratropium
Strength: 500mcg per 2mL respule
Drug Class: Short-Acting Muscarinic Antagonist (SAMA) / Anticholinergic Bronchodilator
Therapeutic Category: Respiratory Bronchodilator
Primary Function: Reduces cholinergic-mediated bronchoconstriction

Ipratropium is the anticholinergic component of IPRALITE DUO RESPULES. It blocks muscarinic receptors in airway smooth muscle and reduces vagally mediated bronchoconstriction.

This action contributes to airway relaxation and improved airflow.

2. Levosalbutamol – 1.25mg

Active Ingredient: Levosalbutamol (Levalbuterol)
Strength: 1.25mg per 2mL respule
Drug Class: Short-Acting Beta-2 Adrenergic Receptor Agonist (SABA)
Therapeutic Category: Respiratory Bronchodilator
Primary Function: Relaxes bronchial smooth muscle

Levosalbutamol is the pharmacologically active R-enantiomer of salbutamol. It primarily stimulates beta-2 adrenergic receptors in bronchial smooth muscle.

Activation of these receptors increases intracellular cyclic AMP and promotes relaxation of bronchial smooth muscle, resulting in bronchodilation.

Key Benefits of IPRALITE DUO RESPULES

Complementary Bronchodilation

Ipratropium and Levosalbutamol work through different receptor pathways to promote airway relaxation.

Supports Improved Airflow

Bronchodilation can help reduce airflow limitation and relieve bronchospasm in appropriate respiratory conditions.

Dual Pharmacological Action

The combination provides both anticholinergic and beta-2 agonist bronchodilator activity within one formulation.

Nebulized Dosage Form

The respule formulation allows administration through a compatible nebulization device when prescribed by a healthcare professional.

Useful in Appropriate Obstructive Airway Conditions

The combination can be clinically useful when both short-acting muscarinic blockade and beta-2 agonist bronchodilation are indicated.

Convenient Fixed-Dose Combination

Two complementary bronchodilators are provided in a single respule formulation for prescribed nebulized treatment.

How Does Ipratropium 500mcg + Levosalbutamol 1.25mg Work?

Ipratropium 500mcg + Levosalbutamol 1.25mg produces bronchodilation through two complementary mechanisms.

Ipratropium is a short-acting muscarinic antagonist. It blocks muscarinic receptors, particularly M3 receptors, on airway smooth muscle. This reduces the effect of acetylcholine-mediated parasympathetic bronchoconstriction and helps relax the airways.

Levosalbutamol acts primarily as a beta-2 adrenergic receptor agonist. Activation of beta-2 receptors increases intracellular cyclic AMP through stimulation of adenylate cyclase. This promotes relaxation of bronchial smooth muscle and produces bronchodilation.

By targeting cholinergic bronchoconstriction and beta-2-mediated smooth-muscle relaxation simultaneously, the Ipratropium + Levosalbutamol mechanism of action provides complementary airway-opening effects.

The clinical response depends on the underlying respiratory condition, disease severity, prescribed treatment regimen, and individual patient factors.

Directions for Use

IPRALITE DUO RESPULES is intended for administration by nebulization through a suitable nebulizer device, as prescribed by a healthcare professional.

  • Use the respule according to the instructions provided with the nebulizer and product packaging.
  • Do not swallow the respule contents.
  • Do not use the solution by an alternative route.
  • Use the prescribed amount at the recommended frequency.
  • Do not independently increase the dose or frequency.
  • Avoid contact of the nebulized solution with the eyes.
  • Do not mix the solution with other medicines in the nebulizer unless specifically instructed by a healthcare professional.
  • Follow the prescribed treatment schedule.
  • Do not discontinue regular therapy without medical advice.
  • Dosage and treatment duration should be determined by the treating physician.
  • If acute or worsening breathlessness does not improve with the prescribed treatment, seek urgent medical attention.

Possible Side Effects

Common Side Effects

Possible adverse effects associated with Ipratropium and Levosalbutamol may include:

  • Dry mouth
  • Headache
  • Dizziness
  • Cough or throat irritation
  • Tremor
  • Nervousness or restlessness
  • Palpitations
  • Increased heart rate
  • Nausea
  • Muscle cramps

Not every patient experiences these effects, and their severity can vary.

Important Adverse Reactions

Important reactions requiring medical attention may include:

  • Paradoxical bronchospasm or worsening breathing immediately after inhalation
  • Significant palpitations or cardiac rhythm disturbances
  • Hypersensitivity reactions, including rash, swelling, or difficulty breathing
  • Eye pain, blurred vision, or visual halos if nebulized medication reaches the eyes
  • Urinary retention, particularly in susceptible individuals
  • Significant hypokalemia with excessive beta-2 agonist exposure

Seek immediate medical attention for severe breathing difficulty, facial or throat swelling, severe chest symptoms, or other serious reactions.

Safety Information

Use Ipratropium 500mcg + Levosalbutamol 1.25mg under appropriate medical supervision.

  • Do not use in patients with known hypersensitivity to Ipratropium, Levosalbutamol, atropine-like compounds, or any formulation component.
  • Use caution in patients with narrow-angle glaucoma because Ipratropium reaching the eyes may increase intraocular pressure.
  • Patients with prostatic enlargement or bladder-outflow obstruction may require additional caution because anticholinergic effects can contribute to urinary retention.
  • Patients with cardiovascular disease, arrhythmias, hypertension, hyperthyroidism, diabetes, or seizure disorders should inform their healthcare professional before treatment.
  • Levosalbutamol can cause tremor, tachycardia, palpitations, and changes in serum potassium, particularly with excessive exposure.
  • Concomitant use with other beta-2 agonists or anticholinergic bronchodilators should be reviewed by the treating physician.
  • Beta-blockers may reduce or antagonize the bronchodilator effect of Levosalbutamol and should be considered carefully by the prescriber.
  • Diuretics, corticosteroids, and other medicines that can lower potassium may increase the risk of hypokalemia with beta-2 agonists.
  • MAO inhibitors and tricyclic antidepressants may enhance cardiovascular effects of beta-adrenergic agonists and require medical consideration.
  • Pregnancy use should be based on clinical need and medical supervision.
  • Consult a healthcare professional before use during breastfeeding.
  • Appropriate clinical assessment may be required in patients with significant kidney or liver impairment.
  • Pediatric patients should use this medicine only when specifically prescribed and with an age-appropriate nebulization system and medical supervision.
  • Elderly patients may be more susceptible to cardiovascular, urinary, and anticholinergic adverse effects.
  • Avoid allowing nebulized solution to enter the eyes. Patients using a face mask should ensure a proper fit.
  • Do not drive or operate machinery if dizziness, tremor, visual disturbance, or other symptoms impair alertness or coordination.
  • If wheezing or breathing difficulty worsens immediately after administration, discontinue treatment and seek urgent medical assessment.

Storage Instructions

Store IPRALITE DUO RESPULES in a cool, dry place away from direct sunlight and moisture.

Keep the product out of reach of children and follow the storage instructions printed on the product packaging.

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IPRALITE DUO RESPULES

Composition: Ipratropium 500mcg + Levosalbutamol 1.25mg

Dosage Form: Respule / Nebulizer Solution
Pack Size: 8×5×2.5mL
Manufacturer: Sarian Healthcare

Additional information

Product Name

IPRALITE DUO RESPULES

Generic Name

Ipratropium + Levosalbutamol

Composition

Each 2 ml Respule contains: Ipratropium 500mcg + Levosalbutamol 1.25 mg

Dosage Form

Therapeutic Categories

Drug Class

Bronchodilator – Anticholinergic & Beta-2 Agonist

Indication

Bronchospasm associated with obstructive airway diseases

Target Infections - Conditions

Bronchospasm & Obstructive Airway Disease

Strength

Ipratropium 500 mcg + Levosalbutamol 1.25 mg / 2 mL

Pack Size

8X5X2.5 ml

Packaging Type

Respule

Storage Conditions

Store in a cool and dry place below 25?C. Protect from moisture and direct sunlight.

Prescription Status

Rx (To be taken under medical supervision)

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Product FAQ

Q1. What is Ipratropium 500mcg + Levosalbutamol 1.25mg used for?

Ipratropium 500mcg + Levosalbutamol 1.25mg is a short-acting bronchodilator combination used to relieve bronchospasm and airflow limitation in appropriate obstructive airway conditions when combination therapy is prescribed.

Q2. What are Ipratropium and Levosalbutamol?

Ipratropium is a short-acting muscarinic antagonist that reduces cholinergic bronchoconstriction. Levosalbutamol is a short-acting beta-2 agonist that relaxes bronchial smooth muscle. Both are bronchodilators but act through different pathways.

Q3. How does Ipratropium 500mcg + Levosalbutamol 1.25mg work?

Ipratropium blocks muscarinic receptors involved in airway constriction, while levosalbutamol stimulates beta-2 receptors to relax bronchial smooth muscle. Their complementary actions produce bronchodilation.

Q4. What are the benefits of Ipratropium 500mcg + Levosalbutamol 1.25mg?

The combination provides complementary bronchodilator activity, supports airway relaxation and airflow, and delivers both anticholinergic and beta-2 agonist actions through a convenient nebulized dosage form.

Q5. What is IPRALITE DUO RESPULES?

IPRALITE DUO RESPULES is a Sarian Healthcare nebulization formulation containing Ipratropium 500mcg + Levosalbutamol 1.25mg in each 2mL respule, supplied in an 8×5×2.5mL pack.

Q6. How should Ipratropium 500mcg + Levosalbutamol 1.25mg respules be used?

The formulation is intended for nebulization using a compatible nebulizer as prescribed by a healthcare professional. The exact dosage and treatment frequency should be determined according to the patient\'s clinical requirements.

Q7. What are the common side effects of Ipratropium + Levosalbutamol?

Possible side effects include dry mouth, tremor, headache, dizziness, cough or throat irritation, nervousness, palpitations, increased heart rate, nausea, and muscle cramps.

Q8. Who should use caution with Ipratropium 500mcg + Levosalbutamol 1.25mg?

Caution may be required in patients with cardiovascular disease, arrhythmias, glaucoma, prostatic enlargement, urinary obstruction, hyperthyroidism, diabetes, or other relevant medical conditions. The treating healthcare professional should review the patient\'s medical history and medicines.

Q9. How should Ipratropium + Levosalbutamol respules be stored?

Store the respules in a cool, dry place away from direct sunlight and moisture. Keep them out of reach of children and follow the storage instructions printed on the product packaging.

Q10. Where can healthcare professionals or pharmaceutical distributors source Ipratropium + Levosalbutamol products from Sarian Healthcare?

Healthcare professionals, distributors, stockists, wholesalers, and institutional procurement teams can contact Sarian Healthcare regarding the availability and pharmaceutical supply of Ipratropium 500mcg + Levosalbutamol 1.25mg respules. Commercial terms and supply requirements should be confirmed directly with the company.

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