Description
SARISOM HP KIT – Clarithromycin 500mg + Esomeprazole 40mg
SARISOM HP KIT contains a combination of Clarithromycin 500mg and Esomeprazole 40mg, bringing together antibacterial activity and gastric acid suppression in a coordinated pharmaceutical kit.
Clarithromycin is a macrolide antibiotic that works by inhibiting bacterial protein synthesis, while Esomeprazole is a proton pump inhibitor (PPI) that reduces gastric acid secretion. The combination is particularly relevant to physician-directed treatment strategies involving Helicobacter pylori (H. pylori), where clarithromycin may be included as part of an appropriate multi-drug eradication regimen and esomeprazole provides gastric acid suppression.
SARISOM HP KIT contains Clarithromycin IP 500mg film-coated tablets and Esomeprazole Magnesium Trihydrate IP equivalent to Esomeprazole 40mg gastro-resistant tablets. The product is supplied as a 10 × 1 kit, with the specified dosage forms included in each kit.
The Clarithromycin 500mg + Esomeprazole 40mg uses should be determined by the treating physician according to the diagnosed infection, local antimicrobial resistance considerations, previous antibiotic exposure, and the complete treatment regimen.
Clarithromycin and esomeprazole provide complementary pharmacological actions, but they should not automatically be considered a complete H. pylori eradication regimen when used alone. The complete treatment approach should be selected by a qualified healthcare professional.
SARISOM HP KIT Composition
Each kit contains:
- Clarithromycin IP – 500mg film-coated tablet
- Esomeprazole Magnesium Trihydrate IP equivalent to Esomeprazole – 40mg gastro-resistant tablet
- Pack Size: 10 × 1 Kit
What Is SARISOM HP KIT Used For?
SARISOM HP KIT combines an antibacterial medicine with an acid-suppressing medicine for physician-directed treatment regimens.
Clarithromycin 500mg provides antibacterial activity against susceptible microorganisms by interfering with bacterial protein synthesis.
Esomeprazole 40mg reduces gastric acid secretion by inhibiting the gastric proton pump.
The combination is particularly relevant to selected H. pylori treatment strategies, where clarithromycin may be used when clinically appropriate and when susceptibility and treatment-history considerations support its use.
The specific use, dosage, duration, and complete treatment combination should always be determined by the treating physician.
Key Ingredients and Their Functions
1. Clarithromycin – 500mg
Active Ingredient: Clarithromycin IP
Strength: 500mg per film-coated tablet
Drug Class: Macrolide antibiotic
Therapeutic Category: Antibacterial / Anti-infective
Primary Function: Inhibits bacterial protein synthesis
Clarithromycin is the antibacterial component of SARISOM HP KIT. It works by binding to the 50S subunit of bacterial ribosomes, thereby interfering with bacterial protein synthesis and inhibiting the growth of susceptible microorganisms.
Its clinical use depends on the susceptibility of the causative organism and the indication for which it has been prescribed.
2. Esomeprazole – 40mg
Active Ingredient: Esomeprazole Magnesium Trihydrate IP equivalent to Esomeprazole
Strength: 40mg per gastro-resistant tablet
Drug Class: Proton Pump Inhibitor
Therapeutic Category: Acid-Suppressing Agent / Gastrointestinal Medicine
Primary Function: Reduces gastric acid secretion
Esomeprazole is the S-isomer of omeprazole and belongs to the proton pump inhibitor class. It suppresses gastric acid production by inhibiting the H+/K+-ATPase proton pump in gastric parietal cells.
This reduces both basal and stimulated gastric acid secretion.
Key Benefits of SARISOM HP KIT
Provides Antibacterial Activity
Clarithromycin 500mg inhibits bacterial protein synthesis in susceptible microorganisms and provides the antimicrobial component of the combination.
Provides Gastric Acid Suppression
Esomeprazole 40mg reduces gastric acid secretion through inhibition of the gastric proton pump.
Relevant to Selected H. pylori Treatment Strategies
Clarithromycin may be included in selected H. pylori eradication regimens when clinically appropriate and when treatment history and antimicrobial susceptibility considerations support its use.
Complementary Pharmacological Actions
The two components work through different mechanisms. Clarithromycin provides antibacterial activity, while esomeprazole provides gastric acid suppression.
Defined Combination Kit
SARISOM HP KIT provides the specified clarithromycin and esomeprazole dosage forms together in a coordinated pharmaceutical kit.
Convenient Dosage-Form Combination
The kit contains film-coated clarithromycin tablets and gastro-resistant esomeprazole tablets for use according to the treatment regimen prescribed by the physician.
How Does Clarithromycin 500mg + Esomeprazole 40mg Work?
Clarithromycin 500mg + Esomeprazole 40mg works through two distinct pharmacological mechanisms.
Clarithromycin is a macrolide antibiotic that enters susceptible bacterial cells and binds to the 50S ribosomal subunit. This interferes with bacterial protein synthesis and inhibits the growth of susceptible microorganisms.
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by inhibiting the H+/K+-ATPase proton pump in gastric parietal cells. This reduces gastric acid production.
In H. pylori treatment strategies, these actions may complement one another. Clarithromycin provides antibacterial activity against susceptible H. pylori, while esomeprazole provides gastric acid suppression.
However, the appropriate H. pylori treatment regimen depends on the complete combination of medicines prescribed, local resistance patterns, previous antibiotic exposure, and individual patient factors.
Therefore, SARISOM HP KIT should be used only as part of the treatment regimen specifically selected by the treating physician.
Directions for Use
Use SARISOM HP KIT strictly as prescribed by the physician.
The kit contains separate clarithromycin and esomeprazole dosage forms. Each component should be taken according to the prescribed treatment regimen.
- Esomeprazole gastro-resistant tablets should generally be swallowed whole and should not be crushed or chewed unless product-specific instructions state otherwise.
- The timing of esomeprazole in relation to food should follow the product information and physician’s instructions.
- Clarithromycin may be taken with or without food depending on the prescribed formulation and product instructions.
- Dosage and treatment duration should be determined by the treating physician.
- Do not independently change the antibiotic dose or treatment duration.
- Complete the prescribed antibiotic course unless the treating physician advises otherwise.
- Do not discontinue antibiotic treatment prematurely simply because symptoms improve.
- If a dose is missed, follow the healthcare professional’s or product information’s instructions rather than doubling the next dose.
Possible Side Effects
The combination may be associated with certain side effects.
Commonly reported effects may include:
- Nausea
- Vomiting
- Abdominal discomfort
- Diarrhea
- Headache
- Altered or metallic taste
- Indigestion or gastrointestinal discomfort
Clarithromycin can particularly cause taste disturbance and gastrointestinal symptoms, while headache and gastrointestinal effects can occur with esomeprazole.
Important Adverse Reactions
Important reactions associated with clarithromycin may include:
- Severe allergic or hypersensitivity reactions
- Severe or persistent diarrhea associated with antibiotic treatment
- Liver injury or significant liver enzyme abnormalities
- QT interval prolongation
- Serious cardiac rhythm disturbances in susceptible individuals
Important reactions associated with esomeprazole and prolonged PPI therapy may include:
- Severe hypersensitivity reactions
- Severe or persistent diarrhea
- Low magnesium levels with prolonged use in susceptible patients
- Vitamin B12 deficiency with prolonged treatment in certain patients
- Acute tubulointerstitial nephritis
Seek prompt medical attention for severe allergic symptoms, fainting, significant palpitations, severe persistent diarrhea, jaundice, or other serious or unusual reactions.
Safety Information
SARISOM HP KIT should be used only under appropriate medical supervision.
- Do not use in individuals with a known serious hypersensitivity to clarithromycin, other macrolide antibiotics, esomeprazole, substituted benzimidazoles, or any formulation component.
- Clarithromycin has important drug-interaction and cardiac safety considerations. Inform the physician about all medicines being taken.
- Clarithromycin should generally be avoided with certain medicines that can cause serious cardiac arrhythmias or clinically significant drug interactions.
- The physician should review the complete medication list before prescribing.
- Clarithromycin is contraindicated with certain medicines, including some ergot alkaloids, specific lipid-lowering agents, and drugs highly dependent on CYP3A metabolism, depending on the individual medicine and clinical circumstances.
- Patients with a history of QT prolongation, ventricular arrhythmias, significant electrolyte abnormalities, or certain cardiac conditions require careful medical assessment.
- Dose adjustment or alternative treatment may be required in significant renal impairment, particularly for clarithromycin.
- Patients with liver disease should inform their physician before treatment.
- Pregnancy and breastfeeding use should be considered only when the treating physician determines that treatment is appropriate.
- Pediatric use should be determined by a healthcare professional according to age, body weight, indication, and formulation.
- Elderly patients may have increased susceptibility to drug interactions and adverse effects.
- Long-term or repeated esomeprazole treatment should be medically reviewed when appropriate.
- Esomeprazole can alter gastric pH and may affect the absorption of medicines whose absorption depends on gastric acidity.
- Complete medication reconciliation is important because both components can be associated with clinically relevant drug interactions.
- Avoid self-medication with antibiotics.
- Do not use leftover clarithromycin for an undiagnosed infection.
- Antibiotic selection for H. pylori should consider current treatment recommendations and clarithromycin resistance patterns.
- Follow individual product instructions regarding food and administration.
- Patients experiencing dizziness, confusion, or other symptoms that could impair alertness should exercise caution while driving or operating machinery.
Storage Instructions
Store SARISOM HP KIT in a cool, dry place away from direct sunlight and moisture.
Keep the medicine out of reach of children and follow the storage conditions printed on the product packaging.
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SARISOM HP KIT
Composition: Clarithromycin IP 500mg + Esomeprazole Magnesium Trihydrate IP equivalent to Esomeprazole 40mg
Dosage Forms: Film-Coated Tablet + Gastro-Resistant Tablet
Pack Size: 10 × 1 Kit
Manufacturer: Sarian Healthcare
