Budesonide 0.5mg & Levosalbutamol 1.25mg | BUDOWELL-L RESPULES

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Combination respule containing budesonide 0.5mg and levosalbutamol 1.25mg.

Product Specifications

Composition: Each 2 ml Respulle contains: Budesonide 0.5 mg + Levosalbutamol 1.25 mg
Dosage Form: Drops
SKU: BUDOWELL-L 500 / 1.25 RESPULES Category: Tags: , , , , Brand:

Description

BUDOWELL-L 500/1.25 RESPULES

Composition: Budesonide 0.5mg + Levosalbutamol 1.25mg per 2mL Respule
Pack Size: 8 × 5 × 2mL
Manufacturer: Sarian Healthcare

Budesonide 0.5mg + Levosalbutamol 1.25mg Respules

BUDOWELL-L 500/1.25 RESPULES contains Budesonide 0.5mg + Levosalbutamol 1.25mg in each 2mL respule. It is an inhaled combination of a corticosteroid and a short-acting bronchodilator used under medical supervision for respiratory conditions involving airway inflammation and bronchospasm.

Budesonide helps reduce inflammatory activity within the airways, while levosalbutamol provides bronchodilation by relaxing bronchial smooth muscle. The combination therefore provides complementary anti-inflammatory and airway-opening effects when both treatment approaches are clinically appropriate.

Budesonide belongs to the inhaled corticosteroid/glucocorticoid class and primarily acts on airway inflammation. Levosalbutamol, also known as levalbuterol, is a selective short-acting beta2-adrenergic receptor agonist that stimulates beta2 receptors in bronchial smooth muscle and promotes bronchodilation.

The clinical positioning of Budesonide + Levosalbutamol depends on the patient’s respiratory diagnosis, symptom pattern, treatment history, and physician assessment. It should not be assumed to be appropriate for every cause of breathlessness or cough.

For healthcare professionals, distributors, stockists, and procurement teams searching for a Budesonide 0.5mg + Levosalbutamol 1.25mg pharmaceutical product, Budesonide respules supplier, or respiratory medicine manufacturer, BUDOWELL-L 500/1.25 RESPULES is a Sarian Healthcare pharmaceutical product intended for physician-directed respiratory therapy and professional pharmaceutical sourcing requirements.

Composition

Budesonide 0.5mg

Active Ingredient: Budesonide
Strength: 0.5mg per 2mL respule
Drug Class: Inhaled corticosteroid / glucocorticoid
Therapeutic Category: Respiratory anti-inflammatory medicine
Primary Function: Reduction of airway inflammation

Budesonide activates glucocorticoid receptors and suppresses multiple inflammatory pathways involved in airway inflammation.

Levosalbutamol 1.25mg

Active Ingredient: Levosalbutamol (Levalbuterol)
Strength: 1.25mg per 2mL respule
Drug Class: Short-acting selective beta2-adrenergic receptor agonist (SABA)
Therapeutic Category: Bronchodilator
Primary Function: Relaxation of bronchial smooth muscle

Levosalbutamol stimulates beta2-adrenergic receptors, increases intracellular cyclic AMP, and produces bronchodilation.

What Is Budesonide + Levosalbutamol Used For?

Budesonide + Levosalbutamol combination therapy may be used under medical supervision for respiratory conditions involving airway inflammation and bronchospasm, where an inhaled corticosteroid together with a short-acting bronchodilator is clinically appropriate.

The two active ingredients address different aspects of airway symptoms:

  • Budesonide helps reduce airway inflammation.
  • Levosalbutamol helps relax bronchial smooth muscle and promote bronchodilation.

The appropriate clinical use depends on the patient’s respiratory diagnosis, symptoms, previous treatment, and physician’s assessment.

The combination should not automatically be considered appropriate for every cause of cough, wheezing, or breathlessness.

Key Ingredients and Their Functions

Budesonide

Budesonide is an inhaled glucocorticoid corticosteroid. It primarily works on inflammatory processes within the respiratory tract.

After reaching airway tissues, it interacts with intracellular glucocorticoid receptors and influences gene transcription involved in inflammation. This reduces the production and activity of multiple inflammatory mediators.

Levosalbutamol

Levosalbutamol, also known as levalbuterol, is a selective short-acting beta2-adrenergic receptor agonist.

It stimulates beta2 receptors on bronchial smooth muscle and increases intracellular cyclic AMP. This promotes relaxation of bronchial smooth muscle and produces bronchodilation.

Key Benefits of BUDOWELL-L 500/1.25 RESPULES

  • Complementary respiratory action: Combines an inhaled corticosteroid with a short-acting bronchodilator.
  • Airway inflammation control: Budesonide helps reduce inflammatory activity within the airways.
  • Bronchodilation: Levosalbutamol promotes relaxation of bronchial smooth muscle and supports improved airflow.
  • Nebulized administration: The 2mL respule format enables administration through an appropriate nebulization system when prescribed.
  • Dual pharmacological pathway: The ingredients work through different mechanisms to provide complementary effects.
  • Convenient combination formulation: A single respule contains both specified active ingredients for physician-directed respiratory management.

How Does Budesonide 0.5mg + Levosalbutamol 1.25mg Work?

BUDOWELL-L 500/1.25 RESPULES works through two complementary pharmacological mechanisms.

Action of Budesonide

Budesonide is an inhaled glucocorticoid. It enters airway cells and binds to intracellular glucocorticoid receptors.

This interaction influences gene transcription and reduces the production and activity of inflammatory mediators. The resulting anti-inflammatory activity helps reduce airway inflammation and related inflammatory changes.

Action of Levosalbutamol

Levosalbutamol is a selective short-acting beta2-adrenergic receptor agonist.

It binds to beta2 receptors on bronchial smooth muscle and activates adenylate cyclase, increasing intracellular cyclic AMP. This promotes relaxation of bronchial smooth muscle and produces bronchodilation.

Combined Action

Together, the two ingredients address two important components of obstructive airway symptoms:

Airway inflammation → Budesonide

Bronchoconstriction → Levosalbutamol

The exact therapeutic role of the combination depends on the patient’s clinical condition and physician-directed treatment plan.

Directions for Use

Use BUDOWELL-L 500/1.25 RESPULES only as prescribed by a qualified healthcare professional.

  • The respule is intended for inhalation through an appropriate nebulization device.
  • Do not swallow the respule contents.
  • Do not use the product by injection.
  • The exact dosage, frequency, nebulizer requirements, and treatment duration should be determined by the treating physician.
  • Use the product according to the prescribed nebulization procedure and the manufacturer’s instructions for the nebulizer.
  • Do not change the prescribed dose or frequency independently.
  • Rinse the mouth after inhalation to help reduce the risk of oral candidiasis associated with inhaled corticosteroid therapy.
  • If a face mask is used, ensure appropriate fitting and wash the face after treatment if medication deposits on the skin.
  • Do not use additional doses for acute breathing symptoms unless specifically instructed by the physician.
  • Do not discontinue prescribed corticosteroid-containing treatment without medical advice.

Dosage and treatment duration should be determined by the treating physician according to the patient’s clinical condition and response to therapy.

Possible Side Effects

Possible side effects associated with Budesonide + Levosalbutamol therapy may include:

  • Headache
  • Tremor
  • Nervousness or restlessness
  • Throat irritation
  • Cough
  • Hoarseness or voice changes
  • Dry mouth
  • Nausea
  • Palpitations or increased awareness of heartbeat
  • Muscle cramps
  • Oral or throat candidiasis

Not every patient experiences these effects.

Important Adverse Reactions

Clinically important reactions may include:

  • Paradoxical bronchospasm or worsening breathing immediately after inhalation
  • Hypersensitivity reactions, including rash, swelling, or bronchospasm
  • Significant tachycardia or cardiac rhythm disturbances
  • Hypokalemia or other metabolic effects associated with beta2-agonist therapy
  • Systemic corticosteroid effects with prolonged or substantial corticosteroid exposure
  • Adrenal suppression
  • Reduced bone mineral density with prolonged corticosteroid exposure
  • Cataracts or glaucoma with long-term corticosteroid exposure

Severe breathing difficulty, facial or throat swelling, significant palpitations, or other serious symptoms require prompt medical attention.

Safety Information

Use Budesonide + Levosalbutamol only according to the prescribing physician’s instructions.

  • Hypersensitivity: Avoid use in patients with a known allergy to budesonide, levosalbutamol, or any component of the formulation.
  • Acute symptoms: The appropriate treatment for sudden severe bronchospasm should be determined by the treating clinician. Do not automatically rely on this combination as an emergency rescue treatment.
  • Cardiovascular conditions: Levosalbutamol may cause cardiovascular effects. Patients with heart disease, arrhythmias, hypertension, or other cardiovascular disorders should inform their physician.
  • Diabetes: Beta2-agonists may affect blood glucose levels in susceptible individuals.
  • Electrolytes: Levosalbutamol can contribute to reduced serum potassium in susceptible patients, particularly when combined with other medicines affecting potassium.
  • Thyroid disorders: Use cautiously in patients with hyperthyroidism or other thyroid disorders.
  • Seizure disorders: Inform the physician about a history of seizures before treatment.
  • Infections: Prolonged inhaled corticosteroid exposure may increase susceptibility to certain local or systemic infections.
  • Kidney impairment: Patients with renal impairment should inform their physician so overall treatment can be appropriately assessed.
  • Liver impairment: Severe hepatic impairment may affect corticosteroid exposure and should be medically supervised.
  • Pregnancy: Use during pregnancy only when clinically indicated and under medical supervision.
  • Breastfeeding: Consult the treating physician before using this combination during lactation.
  • Pediatric patients: Pediatric use should be based on the specific formulation, indication, age, and physician’s assessment. Prolonged corticosteroid exposure may require monitoring of growth and other systemic effects.
  • Elderly patients: Older patients may require monitoring for cardiovascular, metabolic, and corticosteroid-related effects.
  • Drug interactions: Inform the physician about beta-blockers, other beta2-agonists, diuretics, corticosteroids, medicines affecting potassium, tricyclic antidepressants, monoamine oxidase inhibitors, and other regular medicines.
  • Driving: If tremor, dizziness, palpitations, or other symptoms impair alertness or coordination, avoid driving or operating machinery until medically safe.

Storage Instructions

Store BUDOWELL-L 500/1.25 RESPULES in a cool, dry place away from direct sunlight and moisture.

Keep out of reach of children and follow the storage instructions printed on the product packaging.

Sarian Healthcare – Pharmaceutical Company in Gujarat

Sarian Healthcare is a pharmaceutical company in Gujarat serving professional healthcare and pharmaceutical supply requirements across multiple therapeutic segments.

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BUDOWELL-L 500/1.25 RESPULES – Product Summary

BUDOWELL-L 500/1.25 RESPULES contains Budesonide 0.5mg + Levosalbutamol 1.25mg per 2mL respule.

Budesonide provides inhaled corticosteroid anti-inflammatory activity, while levosalbutamol provides short-acting bronchodilator activity. The two ingredients work through complementary pharmacological mechanisms for physician-directed respiratory therapy where combination treatment is clinically appropriate.

Product: BUDOWELL-L 500/1.25 RESPULES
Composition: Budesonide 0.5mg + Levosalbutamol 1.25mg
Dosage Form: 2mL Respule
Pack Size: 8 × 5 × 2mL
Manufacturer: Sarian Healthcare

Additional information

Product Name

BUDOWELL-L 500 / 1.25 RESPULES

Generic Name

Budesonide + Levosalbutamol

Composition

Each 2 ml Respulle contains: Budesonide 0.5 mg + Levosalbutamol 1.25 mg

Dosage Form

Therapeutic Categories

Drug Class

Inhaled Corticosteroid & Short-Acting Beta-2 Agonist

Indication

Bronchospasm associated with obstructive airway diseases

Target Infections - Conditions

Bronchospasm & Obstructive Airway Disease

Strength

Budesonide 0.5 mg + Levosalbutamol 1.25 mg / 2 mL

Pack Size

8X5X2 ml

Packaging Type

Respule

Storage Conditions

Store in a cool and dry place below 25?C. Protect from moisture and direct sunlight.

Prescription Status

Rx (To be taken under medical supervision)

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Product FAQ

Q1. What is Budesonide 0.5mg + Levosalbutamol 1.25mg used for?

Budesonide 0.5mg + Levosalbutamol 1.25mg is an inhaled corticosteroid-bronchodilator combination used under medical supervision for appropriate respiratory conditions involving airway inflammation and bronchospasm.

Q2. What is Budesonide and which drug class does it belong to?

Budesonide is an inhaled corticosteroid belonging to the glucocorticoid class. It primarily reduces airway inflammation through glucocorticoid receptor-mediated activity.

Q3. What is Levosalbutamol 1.25mg and how does it work?

Levosalbutamol 1.25mg is a short-acting selective beta2-adrenergic receptor agonist. It increases intracellular cyclic AMP in bronchial smooth muscle and promotes bronchodilation.

Q4. What are the benefits of Budesonide 0.5mg + Levosalbutamol 1.25mg?

The combination provides complementary anti-inflammatory and bronchodilator activity. Budesonide helps control airway inflammation, while levosalbutamol helps relax bronchial smooth muscle.

Q5. What is BUDOWELL-L 500/1.25 RESPULES?

BUDOWELL-L 500/1.25 RESPULES is a Sarian Healthcare respiratory product containing Budesonide 0.5mg + Levosalbutamol 1.25mg in each 2 mL respule for physician-directed nebulized administration.

Q6. How should Budesonide 0.5mg + Levosalbutamol 1.25mg respules be used?

Budesonide 0.5mg + Levosalbutamol 1.25mg respules should be administered by inhalation through an appropriate nebulizer as prescribed. The physician determines the dose, frequency, and treatment duration.

Q7. What are the common side effects of Budesonide + Levosalbutamol?

Possible side effects include headache, tremor, throat irritation, cough, hoarseness, oral candidiasis, nausea, muscle cramps, and palpitations. Individual responses can vary.

Q8. Who should use caution with Budesonide + Levosalbutamol?

Patients with cardiovascular disease, arrhythmias, hypertension, diabetes, hyperthyroidism, seizure disorders, glaucoma, cataracts, osteoporosis risk, or recurrent infections should inform their physician before treatment.

Q9. Should the mouth be rinsed after Budesonide + Levosalbutamol nebulization?

Yes. Rinsing the mouth after nebulized budesonide therapy can help remove residual corticosteroid from the oral cavity and reduce the risk of oral thrush.

Q10. Where can healthcare professionals or pharmaceutical distributors source Budesonide + Levosalbutamol products from Sarian Healthcare?

Healthcare professionals, distributors, stockists, and pharmaceutical procurement teams can contact Sarian Healthcare regarding availability, commercial requirements, and sourcing of BUDOWELL-L 500/1.25 RESPULES.